Sensing of ceftazidime antibiotics in human plasma through waveguide-enhanced Raman spectroscopy assisted by a mesoporous layer
We report, to the best of our knowledge, the first Raman sensor for antibiotics spiked in human plasma using silicon nitride waveguides functionalized with a mesoporous silica top-cladding. Leveraging waveguiding signal enhancement, chemical enrichment, and molecular sieving, we demonstrate detection of 1 mg/l ceftazidime in plasma within 2 min. Ceftazidime quantification is achieved in plasma over 0, 20, 40, and 60 mg/l, demonstrating its potential for clinical use. Requiring minimal sample preparation, this method has great potential for point-of-need monitoring for optimal antibiotic therapy.
Authors
- André G. Skirtach (ORCID: https://orcid.org/0000-0002-4468-7620)
- Himanshu Sekhar Jena (ORCID: https://orcid.org/0000-0002-5869-5226)
- Pascal Van Der Voort (ORCID: https://orcid.org/0000-0002-1248-479X)
- Nuria Teigell Benéitez (ORCID: https://orcid.org/0000-0002-2209-7857)
- Haolan Zhao (ORCID: https://orcid.org/0000-0003-3990-1634)
- Roel Baets (ORCID: https://orcid.org/0000-0003-1266-1319)
Institutions
- Ablynx (Belgium) (BE)
- HOGENT University of Applied Sciences and Arts (BE)
- Ghent University Hospital (BE)
- Ghent University (BE)
Publication Details
- Journal
- Ghent University Academic Bibliography (Ghent University)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1063/5.0278252
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- European Research Council