Identification of MAPK3 inhibitors against <i>Leishmania</i> spp. via <i>in silico</i> and <i>in vitro</i> approaches
NSC107522 and NSC84100 are promising MAPK3 inhibitors with species-specific activity. NSC107522 targets <i>L. donovani</i>, while NSC84100 is more effective against <i>L. martiniquensis</i>. These findings provide a foundation for developing targeted therapies against leishmaniasis, but further studies will be needed to determine their <i>in vivo</i> efficacy and optimize MAPK3-targeted drug design.
Authors
- Thitinan Aiebchun (ORCID: https://orcid.org/0000-0001-8155-1602)
- Suradej Siripattanapipong (ORCID: https://orcid.org/0000-0002-2807-1412)
- Namfon Nawattanapaibool (ORCID: https://orcid.org/0009-0003-4318-2510)
- Nathjanan Jongkon
- Kiattawee Choowongkomon (ORCID: https://orcid.org/0000-0002-2421-7859)
- Nutnaree Kumsiri (ORCID: https://orcid.org/0009-0001-8112-3242)
Institutions
- Kasetsart University (TH)
- Mahidol University (TH)
- King Mongkut's University of Technology North Bangkok (TH)
Publication Details
- Journal
- Journal of Veterinary Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4142/jvs.25044
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kasetsart University
- King Mongkut's University of Technology North Bangkok
- Kasetsart University Research and Development Institute