Impact of vaccination behavior on COVID-19 dynamics and economic outcomes

COVID-19 is a highly transmissible respiratory disease that has significantly impacted global health and economies. In this study, we investigated the impact of immunity duration, vaccination behavior, transmission reduction measures, and healthcare timing and duration on COVID-19 dynamics and economic outcomes. Using a mathematical model that integrates epidemiological, human behavioral, and economic factors, we analyzed the effectiveness of interventions based on real-world data. Analytical results revealed up to six disease-free equilibria, with stability determined by reproduction number thresholds. Results from numerical simulations of the model indicated that prolonged immunity and high vaccination rates can reduce peak infections and deaths, whereas delayed hospitalizations and increased transmission can exacerbate outbreaks. Sensitivity analysis highlights vaccine efficacy and uptake as key determinants of disease control. These findings underscore the need for sustained vaccination, timely healthcare interventions, and strategic public health measures.

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Journal
Mathematical Biosciences & Engineering
Published
2025-01-01
DOI
https://doi.org/10.3934/mbe.2025084
Primary Topic
COVID-19 Pandemic Impacts
Type
article
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article

Impact of vaccination behavior on COVID-19 dynamics and economic outcomes

Maia Martcheva, Calistus N. Ngonghala, Abdallah Alsammani
Mathematical Biosciences & Engineering
COVID-19 Pandemic Impacts
article

Impact of vaccination behavior on COVID-19 dynamics and economic outcomes

Maia Martcheva, Calistus N. Ngonghala, Abdallah Alsammani
article en

Abstract

COVID-19 is a highly transmissible respiratory disease that has significantly impacted global health and economies. In this study, we investigated the impact of immunity duration, vaccination behavior, transmission reduction measures, and healthcare timing and duration on COVID-19 dynamics and economic outcomes. Using a mathematical model that integrates epidemiological, human behavioral, and economic factors, we analyzed the effectiveness of interventions based on real-world data. Analytical results revealed up to six disease-free equilibria, with stability determined by reproduction number thresholds. Results from numerical simulations of the model indicated that prolonged immunity and high vaccination rates can reduce peak infections and deaths, whereas delayed hospitalizations and increased transmission can exacerbate outbreaks. Sensitivity analysis highlights vaccine efficacy and uptake as key determinants of disease control. These findings underscore the need for sustained vaccination, timely healthcare interventions, and strategic public health measures.

Mathematical Biosciences & EngineeringVol. 22(9)
Broad Institute (US), Harvard University (US), University of Florida (US), Jacksonville University (US), Harvard Global Health Institute (US)
Zero hunger
Openalex Percentile: Top 72%
COVID-19 Pandemic Impacts
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Impact of vaccination behavior on COVID-19 dynamics and economic outcomes — Maia Martcheva, Calistus N. Ngonghala, et al. · Mathematical Biosciences & Engineering (2025) | TGRS Research Map | TGRS