Inferring a Gene Regulatory Network Involved in Drosophila Melanogaster’s Muscle Development

The potential of Granger causality in identifying gene regulatory networks is investigated, with a specific focus on Drosophila melanogaster muscle development. Our study analyzes gene expression time series recorded across the insect’s lifecycle, spanning embryonic, larval, pupal, and adult stages. The gene-gene regulatory interaction networks published so far show poor agreement, and our findings underscore the importance of longer gene expression time series for reliably identifying gene regulatory networks.