Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework
A series of hydroxy- and alkoxy-substituted isocoumarins were synthesized in one step by the rhodium-catalyzed C-H annulation of benzoic acids with alkynes. 8,9-Diethyl-6<em>H</em>-[1,3]dioxolo[4,5-<em>f</em>]isochromen-6-one and its isoquinolone analog have effectively inhibited the growth of six types of phytopathogenic fungi at 30 mg dm<sup>--3</sup> concentration, the activity exceeding that of the commercial Triadimefon.
Authors
- Olga Chusova (ORCID: https://orcid.org/0000-0002-1319-2481)
- Dmitry A. Loginov (ORCID: https://orcid.org/0000-0002-7512-5057)
- Vladimir B. Kharitonov (ORCID: https://orcid.org/0000-0002-3949-7398)
- Yulia Vladimirovna Nelyubina (ORCID: https://orcid.org/0000-0002-9121-0040)
- А. N. Rodionov (ORCID: https://orcid.org/0000-0001-9227-7434)
- Павел В. Дороватовский (ORCID: https://orcid.org/0000-0002-2978-3614)
- Iolina O Bekshaite
- Kirill A Vasiliev
Institutions
- Kurchatov Institute (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
- Institute of Problems of Chemical Physics (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7777
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Ministry of Education and Science of the Russian Federation
- Russian Science Foundation