Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2<em>H</em>)-furanone with antiradical activity

Target-oriented synthesis of highly functionalized 3(2<em>H</em>)-furanone from vanillin through several alkyne intermediates was realized in six steps. The title compound bearing two 4-hydroxy-3-methoxyphenyl moieties showed antiradical activity 1.54 times higher compared to Trolox.

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Publication Details

Journal
Mendeleev Communications
Published
2025-01-01
DOI
https://doi.org/10.71267/mencom.7727
Primary Topic
Biochemical and biochemical processes
Type
article
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article

Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity

Olesya Viktorovna Shabalina, Dmitrii A. Shabalin
Mendeleev Communications
Biochemical and biochemical processes
article

Unveiling an underestimated potential of vanillin-derived alkynes: synthesis of highly functionalized 3(2H)-furanone with antiradical activity

Olesya Viktorovna Shabalina, Dmitrii A. Shabalin
article en

Abstract

Target-oriented synthesis of highly functionalized 3(2<em>H</em>)-furanone from vanillin through several alkyne intermediates was realized in six steps. The title compound bearing two 4-hydroxy-3-methoxyphenyl moieties showed antiradical activity 1.54 times higher compared to Trolox.

Mendeleev CommunicationsVol. 35(5)
A.E. Favorsky Irkutsk Institute of Chemistry (RU), Irkutsk State University (RU)
Openalex Percentile: Top 77%
Biochemical and biochemical processes
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