Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress
This study provides the first evidence that MSA ameliorates AIH by suppressing the IFN-γ-Janus tyrosine kinase 1/2-signal transducer and activator of transcription 1 signaling pathway, offering novel mechanistic insights and a promising therapeutic candidate for the future treatment of autoimmune disorders.
Authors
- Kun Zhang (ORCID: https://orcid.org/0000-0002-2324-9381)
- Tao Han (ORCID: https://orcid.org/0000-0003-4216-6968)
- Jiajun Wang (ORCID: https://orcid.org/0000-0001-9524-7310)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4927-1867)
- Hong Wei (ORCID: https://orcid.org/0000-0003-1199-4365)
- Yifan He (ORCID: https://orcid.org/0000-0003-2142-3208)
Institutions
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-07-18
- DOI
- https://doi.org/10.14218/jcth.2025.00112
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Tianjin University
- Natural Science Foundation of Tianjin City