One-pot synthesis of acetyl(iso)quinolines/pyridines employing the sodium-promoted Claisen condensation of the corresponding carboxylates
A convenient one-pot synthesis of acetylated quinolines/isoquinolines/pyridines involves the sodium-promoted Claisen condensation of the corresponding ethyl hetarenecarboxylates with ethyl acetate as the reactant and the solvent. The thus formed intermediate ethyl 3-hetaryl-3-oxopropanoates can be decarboxylated in the same reactor by refluxing with 25
Authors
- Xin He (ORCID: https://orcid.org/0000-0002-4667-7215)
- Shuhan Dong
- Di Liu (ORCID: https://orcid.org/0000-0002-1180-5248)
- Yuan Tian (ORCID: https://orcid.org/0009-0000-0994-6968)
- Ziyi Wang (ORCID: https://orcid.org/0009-0005-3334-3266)
- Yi Zou
- Jie Sui
Institutions
- China Pharmaceutical University (CN)
- Shanghai Customs College (CN)
- Changzhou Vocational Institute of Engineering (CN)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7748
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00