New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination
New phosphonium salts synthesized from 5-chloromethyl-8-methyl-7-azacoumarin-3-carboxamides and triphenylphosphine upon the Wittig reaction with aromatic aldehydes give the corresponding 5-styryl-7-azacoumarin derivatives. The cytotoxic activity of some phosphonium salts against cancer cell lines M-HeLa and HuTu-80 is equal to or superior to that of the reference 5-fluorouracil. The IC<sub>50 </sub>and SI values of the leading compounds exceed those for 5-fluorouracil by a factor of 3.7 and 2.2, respectively.
Authors
- Anna P. Lyubina (ORCID: https://orcid.org/0000-0002-2816-8142)
- A. V. Trifonov (ORCID: https://orcid.org/0000-0002-2178-118X)
- М. А. Пудовик
- R. Kh. Bagautdinova (ORCID: https://orcid.org/0000-0002-0101-9411)
- Klara Kh. Darmagambet
- Nurila A. Togyzbayeva (ORCID: https://orcid.org/0000-0003-4310-0661)
- Nurbol Appazov (ORCID: https://orcid.org/0000-0001-8765-3386)
- A. D. Voloshina
- А. Р. Бурилов (ORCID: https://orcid.org/0000-0003-2938-7352)
- Almir S. Gazizov (ORCID: https://orcid.org/0000-0001-9899-9606)
- Рахымжан А. Турманов (ORCID: https://orcid.org/0000-0002-7268-1699)
- L. K. Kibardina (ORCID: https://orcid.org/0000-0002-6035-2118)
- Elena Chugunova (ORCID: https://orcid.org/0000-0002-9371-1877)
- Aiym E. Tolegen
Institutions
- Korkyt Ata Kyzylorda State University (KZ)
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
- Kazan State Technological University (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7750
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education and Science of the Russian Federation
- Ministry of Education and Science of the Republic of Kazakhstan