Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren's syndrome.
In SSDE, IRF-8 is upregulated and associated with clinical features, DC activation, and serological indicators. These findings suggest that IRF-8 plays a critical role in SSDE pathogenesis and may serve as a potential therapeutic target for diagnosis and treatment.
Authors
- Xiaoyu Cai (ORCID: https://orcid.org/0000-0002-8510-2967)
- Zihuan Wang (ORCID: https://orcid.org/0009-0001-0769-3618)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Jiao Wang (ORCID: https://orcid.org/0000-0002-7008-1913)
- Suhua Shi (ORCID: https://orcid.org/0000-0003-2809-5999)
- Guang-Hong Chu
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.18240/ijo.2025.08.05
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00