G-Protein-Coupled Receptor Class C Group 6 Member A (GPRC6A) and Serine Protease Inhibitor, Kazal Type 1 (SPINK1) Genotypes Associated With Refractory Functional Dyspepsia: A Potential Link to Endosonographic Features
Significant differences (p < 0.001) were observed in the ratio of abnormal pancreatic enzyme levels between patients with R-FD and those with FD. <i>GPRC6A</i> genotype was significantly associated with EUS features, and further studies will be needed to clarify the significant association between <i>GPRC6A</i> genotype and EUS score.
Authors
- Takeshi Onda (ORCID: https://orcid.org/0000-0003-4722-1954)
- Shuhei Agawa
- Rie Kawawa
- Seiji Futagami (ORCID: https://orcid.org/0000-0003-0502-8646)
- Mayu Habiro
- Masanori Atsukawa (ORCID: https://orcid.org/0000-0003-3374-7111)
- Ken Nakamura (ORCID: https://orcid.org/0000-0002-9192-182X)
- Tomohide Tanabe
- Nobue Ueki
- S. Higashida
Institutions
- Nippon Medical School Hospital (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-07-18
- DOI
- https://doi.org/10.7759/cureus.88222
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00