From Neoadjuvant Therapy to Surgical Treatment: Combining Management of Central Giant Cell Granuloma of The Mandible in A Pediatric Case

Giant cell granuloma (GCG) of the mandible is a rare, benign but aggressive bone tumor characterized by the presence of multinucleated giant cells resembling osteoclasts. It most commonly affects adults aged 30-50 and typically presents with symptoms such as pain, swelling, tooth mobility, and facial asymmetry. The diagnosis is established through imaging techniques such as X-rays, CT scans, and MRIs, followed by biopsy for histological confirmation. For years, the treatment was essentially based on surgical resection with possible reconstructive surgery and radiation therapy in cases of incomplete excision or recurrence. Prognosis is favorable when complete resection is achieved, but regular follow-up is crucial due to the high potential for recurrence. In some cases, other therapies are mandatory, either as a monotherapy or as neoadjuvant therapy. We report a case of a giant cell granuloma of the mandibula which occurred in a 14 year old male. The patient was initially treated with neoadjuvant intralesional corticosteroid injections, resulting in a significant reduction of the lesion. Subsequently, the patient underwent surgical curettage to remove the remaining mass.