Elevated CD4⁺/CD8⁺ ratio and D-dimer as diagnostic biomarkers for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis versus infectious mononucleosis in children: a retrospective case-control study
Elevated CD4⁺/CD8⁺ ratio and D-dimer serve as potential diagnostic biomarkers for pediatric EBV-HLH. Their combined detection enhances differentiation from EBV-IM, though validation through prospective studies is warranted.
Authors
- Yuanyuan Duan (ORCID: https://orcid.org/0000-0002-2886-210X)
- Jingjing Jin (ORCID: https://orcid.org/0000-0001-9683-4402)
- Wangqiang Li
- Wenjia Tong
- Yun Cheng (ORCID: https://orcid.org/0000-0001-5441-0513)
- Biquan Chen
Institutions
- Anhui Provincial Children's Hospital (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12879-025-11440-1
- Citations
- 2
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54