Cognitive and brain health in women with early bilateral salpingo‐oophorectomy: Implications for risk, resilience, and subjective cognitive decline
Oophorectomy in early middle age may be a risk for subjective cognitive decline. Oophorectomy is associated with less gray matter volume in the prefrontal cortex. Estradiol therapy and verbal IQ might be resilience factors mitigating such risk.
Authors
- Marcus Q. Bernardini (ORCID: https://orcid.org/0000-0001-7022-8308)
- Noelia Calvo (ORCID: https://orcid.org/0000-0003-4202-9314)
- Alana Brown (ORCID: https://orcid.org/0000-0002-1237-1314)
- Laurice Karkaby
- Laura L. Gravelsins (ORCID: https://orcid.org/0000-0002-9087-9199)
- Cheryl Grady (ORCID: https://orcid.org/0000-0001-9533-8802)
- Nicole Gervais (ORCID: https://orcid.org/0000-0003-2773-7830)
- Natasha Rajah
- Annie Duchesne (ORCID: https://orcid.org/0000-0001-6049-8785)
- Gillian Einstein (ORCID: https://orcid.org/0000-0002-0770-5471)
- Shreeyaa Ramana (ORCID: https://orcid.org/0009-0006-9010-6184)
- Shuchun Zhao (ORCID: https://orcid.org/0000-0003-0462-768X)
- Elizabeth Hampson (ORCID: https://orcid.org/0000-0003-4487-9013)
- Michelle Jacobson
- Zhuo Shao
Institutions
- Linköping University (SE)
- Western University (CA)
- University Health Network (CA)
- University of Northern British Columbia (CA)
- University of Groningen (NL)
- University of Toronto (CA)
- Douglas Mental Health University Institute (CA)
- North York General Hospital (CA)
- Women's College Hospital (CA)
- Baycrest Hospital (CA)
- Public Health Ontario (CA)
- Linköping University Hospital (SE)
- Toronto Metropolitan University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70454
- Citations
- 2
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- McGill University
- Consortium canadien en neurodégénérescence associée au vieillissement
- Canadian Cancer Society
- Canadian Institutes of Health Research