Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry
We found suggestive evidence that a higher African ancestry proportion is associated with an attenuated increase in the blood p-Tau181 level over time. More research is needed to characterize the longitudinal dynamics of ADRD biomarkers across ancestry and the driving biological or sociocultural factors.
Authors
- Mei Ling Ong (ORCID: https://orcid.org/0000-0002-7676-6921)
- Robert A. Philibert (ORCID: https://orcid.org/0000-0001-7822-4977)
- Steven R. H. Beach (ORCID: https://orcid.org/0000-0001-8053-7761)
- Yitang Sun (ORCID: https://orcid.org/0000-0002-6564-8815)
- Huifang Xu (ORCID: https://orcid.org/0000-0001-7356-2424)
- Charleston W. K. Chiang (ORCID: https://orcid.org/0000-0002-0668-7865)
- Burcu F. Darst (ORCID: https://orcid.org/0000-0002-6205-4632)
- Kaixiong Ye (ORCID: https://orcid.org/0000-0003-4658-7292)
- Man‐Kit Lei (ORCID: https://orcid.org/0000-0002-7757-6548)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Ronald L. Simons (ORCID: https://orcid.org/0000-0002-4902-0462)
- Lu Wang (ORCID: https://orcid.org/0000-0002-1737-686X)
- Yueqi Lu (ORCID: https://orcid.org/0000-0002-0975-5587)
Institutions
- University of Southern California (US)
- University of Iowa (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Georgia (US)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Wake Forest University (US)
- Seattle University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1212/wnl.0000000000213976
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00