Population Pharmacokinetics of Busulfan in Pediatric Patients: Optimization of a Four‐Times‐Daily Dosing Regimen Based on EBMT Recommendations
We developed a Q6H × 4 days busulfan dosing regimen through PopPK modeling. For a representative 6-year-old patient with a bodyweight of 20 kg, the recommended dose is 1.25 mg/kg/dose. Therapeutic drug monitoring following the initial dose remains clinically essential.
Authors
- Yuqing Chen (ORCID: https://orcid.org/0000-0003-3832-3836)
- Junyan Wu (ORCID: https://orcid.org/0000-0003-0870-382X)
- Jiebin Ou
- Ying Wang (ORCID: https://orcid.org/0000-0003-0892-7858)
- Hua Zhu (ORCID: https://orcid.org/0000-0003-2733-7837)
- Chen Ye (ORCID: https://orcid.org/0000-0003-3935-1601)
- Xiaoxia Yu
- Zeyuan He
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1002/pbc.31969
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine