Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn’s disease
The biomarker PRO-C16 was associated with a stricturing disease phenotype, indicating that PRO-C16 may be a potential marker of intestinal fibrosis in CD, with the potential to aid in the clinical development of novel stromal-immune therapeutic agents.
Authors
- Anne‐Christine Bay‐Jensen (ORCID: https://orcid.org/0000-0001-7952-9297)
- Majken Lindholm (ORCID: https://orcid.org/0000-0002-1766-8678)
- Darren Ruane (ORCID: https://orcid.org/0000-0002-1053-2313)
- Giuseppe Mazza (ORCID: https://orcid.org/0000-0002-6644-1429)
- Joachim Høg Mortensen (ORCID: https://orcid.org/0000-0003-0326-7264)
- Paolo Giuffrida (ORCID: https://orcid.org/0000-0001-7164-2439)
- Tina Manon‐Jensen (ORCID: https://orcid.org/0000-0002-2271-4405)
- M.A. Karsdal (ORCID: https://orcid.org/0000-0001-5026-8740)
- Massimo Pinzani (ORCID: https://orcid.org/0000-0003-1398-1541)
- Flavio Caprioli (ORCID: https://orcid.org/0000-0002-8077-8175)
- Luca Pastorelli (ORCID: https://orcid.org/0000-0002-2810-9951)
- Lasse Langholm (ORCID: https://orcid.org/0000-0003-0549-5797)
- Antonio Di Sabatino (ORCID: https://orcid.org/0000-0002-0302-8645)
Institutions
- AOL (United States) (US)
- Royal Free London NHS Foundation Trust (GB)
- University of Milan (IT)
- University of Pavia (IT)
- The Royal Free Hospital (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Nordic Bioscience (Denmark) (DK)
- University College London (GB)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12876-025-04146-w
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00