Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer
We describe an innovative anticancer strategy that fully abides by the rules of chemical biology. We indeed modulate the formation of G4s in cells using ad hoc molecular tools in the aim of disturbing the homeostasis and inner functioning of lncRNAs. By exploiting cellular outcomes, we infer how this pharmacomodulation affects CRC biology and, beyond this, the fate of CRC cells owing to the flawed repertoire of correction and/or compensatory mechanisms in cancer cells.
Authors
- Shubham Sharma (ORCID: https://orcid.org/0000-0001-6658-7762)
- Jérémie Mitteaux (ORCID: https://orcid.org/0000-0003-0839-553X)
- Bhaskar Datta (ORCID: https://orcid.org/0000-0002-9276-2023)
- David Monchaud (ORCID: https://orcid.org/0000-0002-3056-9295)
- Angélique Pipier (ORCID: https://orcid.org/0000-0002-8481-2860)
- Marie‐José Penouilh
- Marc Pirrotta
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bourgogne (FR)
- Indian Institute of Technology Gandhinagar (IN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12915-025-02322-8
- Citations
- 3
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- European Molecular Biology Organization
- Indian Institute of Technology Gandhinagar
- Agence Nationale de la Recherche
- Ligue Contre le Cancer
- Directorate for Biological Sciences