Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis
This integrative study establishes distinct conditioning signatures, suggests molecular mechanisms, and underscores the therapeutic potential of cMSC, offering a robust framework for advancing cell-based therapies in autoimmune diseases.
Authors
- Jean‐Thomas Vilquin (ORCID: https://orcid.org/0000-0003-0050-0219)
- Rozen Le Panse (ORCID: https://orcid.org/0000-0001-7522-5974)
- Danièle Noël (ORCID: https://orcid.org/0000-0002-3498-3776)
- Frédérique Truffault (ORCID: https://orcid.org/0000-0003-1284-8634)
- Axel You
- Natalia Pinzón (ORCID: https://orcid.org/0000-0002-0093-2487)
- Christophe Martinaud (ORCID: https://orcid.org/0000-0001-5439-4699)
- Nadine Dragin (ORCID: https://orcid.org/0000-0002-5250-322X)
- Cinthia Bergman
- Sonia Berrih‐Aknin (ORCID: https://orcid.org/0000-0001-9199-4175)
- Aurélien Corneau (ORCID: https://orcid.org/0000-0003-1272-6872)
- Alexandra Clarissa Bayer (ORCID: https://orcid.org/0000-0003-2863-8148)
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Yale University (US)
- Sorbonne Université (FR)
- Institut National de la Transfusion Sanguine (FR)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- CEA Marcoule (FR)
- Centre de Recherche en Myologie
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s13287-025-04534-9
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Sorbonne Université