Dose Is a Critical Factor Affecting Treatment Volumes for Integrated Nanosecond Pulse Irreversible Electroporation (INSPIRE)
Single applicator INSPIRE treatments significantly simplify treatment planning and clinical implementation versus traditional two to six applicator approaches. This study demonstrates that INSPIRE protocols can rapidly produce large spherical treatment zones while reducing treatment times by an order of magnitude compared to existing electroporation approaches.
Authors
- J. T. Darrow
- Michael B. Sano (ORCID: https://orcid.org/0000-0003-3823-5932)
- Kyle G. Mathews (ORCID: https://orcid.org/0000-0003-3431-6049)
- Callie Fogle (ORCID: https://orcid.org/0000-0002-3058-7290)
- Nathan C. Nelson (ORCID: https://orcid.org/0000-0003-3765-1694)
- David A. Gerber (ORCID: https://orcid.org/0000-0002-7972-5228)
- R Williamson
- Jordan A. Fong
- Logan Reeg
- Alina C. Iuga
Institutions
- University of North Carolina Health Care (US)
- North Carolina State University (US)
- Gradient (United States) (US)
- UNC/NCSU Joint Department of Biomedical Engineering (US)
- University of Cincinnati (US)
Publication Details
- Journal
- IEEE Transactions on Biomedical Engineering
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1109/tbme.2025.3597274
- Citations
- 1
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.23