Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice
Humanized mouse models with transgenic expression of human myelopoiesis-supporting growth factors have enhanced human myeloid cell engraftment and improved the study of human innate immune responses. Here, we discuss the remaining challenges associated with studying innate immunity in humanized NSG-SGM3 and MISTRG mice, as well as potential advances to overcome them.
Authors
- Andy Wullaert (ORCID: https://orcid.org/0000-0001-5012-654X)
- Jolien Van Cleemput (ORCID: https://orcid.org/0000-0003-1598-3057)
- Linos Vandekerckhove (ORCID: https://orcid.org/0000-0002-8600-1631)
- Hannah Stocks
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Ghent University Hospital (BE)
- Ghent University (BE)
- VIB-UGent Center for Inflammation Research (BE)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1016/j.it.2025.07.011
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Fonds Wetenschappelijk Onderzoek
- Universiteit Gent
- Vlaamse regering
- Bijzonder Onderzoeksfonds UGent