Digital pathology and lipid droplet size as a key determinant of discrepancies between histology and MRI gradings in steatotic liver disease
Question Can the size distribution of hepatic lipid droplets (LDs), determined with digital pathology, provide insights into the discordances between histology and MRI-PDFF steatosis grading? Findings There is a 36% disagreement rate between histology and MRI-PDFF. Tiny and small LDs explain discordance, while large LDs favor concordance between both techniques. Clinical relevance MRI-PDFF captures the whole spectrum of LDs size beyond pathologists scoring system and strongly correlates with LDs total content avoiding conventional histology bias.
Authors
- Víctor Puglia (ORCID: https://orcid.org/0000-0002-7863-0294)
- Clara Alfaro‐Cervelló (ORCID: https://orcid.org/0000-0002-3737-4028)
- Ángel Alberich‐Bayarri (ORCID: https://orcid.org/0000-0002-5932-2392)
- Ana Crespo (ORCID: https://orcid.org/0009-0001-3477-144X)
- Amadeo Ten‐Esteve (ORCID: https://orcid.org/0000-0002-3339-7767)
- Matías Fernández-Patón (ORCID: https://orcid.org/0000-0001-9374-1411)
- Claude B. Sirlin (ORCID: https://orcid.org/0000-0002-6639-9072)
- Cristina Montón
- Ana Jiménez-Pastor (ORCID: https://orcid.org/0000-0002-0978-9429)
- David Martí‐Aguado (ORCID: https://orcid.org/0000-0002-4266-6076)
- Alexandre Pérez‐Girbés (ORCID: https://orcid.org/0000-0003-4305-6445)
- Salvador Benlloch (ORCID: https://orcid.org/0000-0002-0794-6937)
- María Pilar Ballester (ORCID: https://orcid.org/0000-0001-7177-5696)
- Desamparados Escudero‐García (ORCID: https://orcid.org/0000-0001-7351-3307)
- Victoria Aguilera (ORCID: https://orcid.org/0000-0001-6492-0357)
- Luis Martí‐Bonmatí (ORCID: https://orcid.org/0000-0002-8234-010X)
- Antonio Ferrández (ORCID: https://orcid.org/0000-0003-3406-3838)
- Judith Pérez‐Rojas (ORCID: https://orcid.org/0000-0002-6091-0888)
- Leonor Cerdá-Alberich (ORCID: https://orcid.org/0000-0002-5567-4278)
- Irene Navarrete-Pérez
Institutions
- Universitat de València (ES)
- Universidad Cardenal Herrera CEU (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- University of California San Diego (US)
- Hospital Arnau de Vilanova (ES)
- Leitat Technological Center (ES)
- Center For Biomarker Research In Medicine (AT)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- INCLIVA Health Research Institute (ES)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- European Radiology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1007/s00330-025-11919-0
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Generalitat Valenciana
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana
- FP7 Science in Society