Cytokine, Chemokine, and Neurofilament Light Chain Signatures in <scp>LGI1</scp> Autoimmune Encephalitis

Elevations in IL-6, IL-8/CXCL8, and IL-17A were identified in this LGI1-AE cohort. CSF IL-6, IL-8/CXCL8, and NfL levels are potential prognostic biomarkers for risk of relapse and chronic epilepsy in LGI1-AE.

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Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2025-08-08
DOI
https://doi.org/10.1002/acn3.70158
Citations
2
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
2.78

Funders

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article

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Yahel Segal‬‏, Michel B. Tolédano, Albert Aboseif, Binxia Yang et al.
2 citations
Annals of Clinical and Translational Neurology
Autoimmune Neurological Disorders and Treatments
2.78
article

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Yahel Segal‬‏, Michel B. Tolédano, Albert Aboseif, Binxia Yang, Αναστασία Ζεκερίδου, Georgios Mangioris, Ivana Vodopivec, A. Sebastian López‐Chiriboga, Eoin P. Flanagan, Charles L. Howe, Sarosh R. Irani, Andrew B. McKeon, Jeffrey W. Britton, Gregory Scott Day, Vanessa Pazdernik, John R. Mills, Sean Joseph Pittock, Divyanshu Dubey
article en
2 citations

Abstract

Elevations in IL-6, IL-8/CXCL8, and IL-17A were identified in this LGI1-AE cohort. CSF IL-6, IL-8/CXCL8, and NfL levels are potential prognostic biomarkers for risk of relapse and chronic epilepsy in LGI1-AE.

Annals of Clinical and Translational NeurologyVol. 12(11)
Roche (Switzerland) (CH), Mayo Clinic (US), Jacksonville College (US), University of Oxford (GB), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Wellcome Trust, National Institute for Health and Care Research, National Institutes of Health, Genentech, Medical Research Council, National Institute of Neurological Disorders and Stroke
Good health and well-being
Openalex Percentile: Top 9%
Autoimmune Neurological Disorders and Treatments
2.78
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