Cytokine, Chemokine, and Neurofilament Light Chain Signatures in <scp>LGI1</scp> Autoimmune Encephalitis
Elevations in IL-6, IL-8/CXCL8, and IL-17A were identified in this LGI1-AE cohort. CSF IL-6, IL-8/CXCL8, and NfL levels are potential prognostic biomarkers for risk of relapse and chronic epilepsy in LGI1-AE.
Authors
- Yahel Segal (ORCID: https://orcid.org/0000-0001-6452-9526)
- Michel B. Tolédano (ORCID: https://orcid.org/0000-0002-3079-1179)
- Albert Aboseif (ORCID: https://orcid.org/0000-0001-5053-8544)
- Binxia Yang (ORCID: https://orcid.org/0000-0003-3043-8479)
- Αναστασία Ζεκερίδου (ORCID: https://orcid.org/0000-0002-1960-9065)
- Georgios Mangioris (ORCID: https://orcid.org/0000-0001-5051-1739)
- Ivana Vodopivec
- A. Sebastian López‐Chiriboga (ORCID: https://orcid.org/0000-0001-5653-5600)
- Eoin P. Flanagan (ORCID: https://orcid.org/0000-0002-6661-2910)
- Charles L. Howe (ORCID: https://orcid.org/0000-0002-3889-8739)
- Sarosh R. Irani (ORCID: https://orcid.org/0000-0002-7667-9748)
- Andrew B. McKeon (ORCID: https://orcid.org/0000-0001-6856-8143)
- Jeffrey W. Britton (ORCID: https://orcid.org/0000-0002-0147-8159)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Vanessa Pazdernik (ORCID: https://orcid.org/0000-0001-7566-7334)
- John R. Mills (ORCID: https://orcid.org/0000-0003-1025-4760)
- Sean Joseph Pittock (ORCID: https://orcid.org/0000-0002-6140-5584)
- Divyanshu Dubey (ORCID: https://orcid.org/0000-0002-4302-4075)
Institutions
- Roche (Switzerland) (CH)
- Mayo Clinic (US)
- Jacksonville College (US)
- University of Oxford (GB)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1002/acn3.70158
- Citations
- 2
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- National Institutes of Health
- Genentech
- Medical Research Council
- National Institute of Neurological Disorders and Stroke