Clinical Significance of CD109 Expression and Methylation Patterns in Acute Myeloid Leukemia

Our results suggest that CD109 exhibits elevated expression and hypomethylation in AML, with its expression being regulated by methylation of its promoter region. Furthermore, CD109 could serve as a prognostic indicator as well as a monitoring tool for the therapeutic outcome in AML.

Authors

Publication Details

Journal
Clinical Laboratory
Published
2025-01-01
DOI
https://doi.org/10.7754/clin.lab.2025.250128
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
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article

Clinical Significance of CD109 Expression and Methylation Patterns in Acute Myeloid Leukemia

Zi‐jun Xu, Ming‐qiang Chu, Jun Qian, Shuangxi Liu et al.
Clinical Laboratory
Histone Deacetylase Inhibitors Research
article

Clinical Significance of CD109 Expression and Methylation Patterns in Acute Myeloid Leukemia

Zi‐jun Xu, Ming‐qiang Chu, Jun Qian, Shuangxi Liu, Tingting Du, Wei Zhao, Jiang Lin, Minjie Zhang, Xiang-mei Wen, Jing-dong Zhou
article en

Abstract

Our results suggest that CD109 exhibits elevated expression and hypomethylation in AML, with its expression being regulated by methylation of its promoter region. Furthermore, CD109 could serve as a prognostic indicator as well as a monitoring tool for the therapeutic outcome in AML.

Clinical LaboratoryVol. 71(08/2025)
Good health and well-being
Openalex Percentile: Top 82%
Histone Deacetylase Inhibitors Research
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