Effect modification in therapeutic impact of nalmefene on alcohol dependence by <i>ADH1B</i> polymorphism: A secondary analysis of a Japanese randomized clinical trial
The ADH1B rs1229984 polymorphism appears to moderate the response to nalmefene in Japanese patients with alcohol dependence. Specifically, nalmefene appears to show efficacy in individuals with the ADH1B rs1229984 AA genotype.
Authors
- Manabu Takaki (ORCID: https://orcid.org/0000-0002-7371-2821)
- Soshi Takao (ORCID: https://orcid.org/0000-0002-7628-1254)
- Yuko Okahisa (ORCID: https://orcid.org/0000-0003-1125-0761)
- Keitaro Matsuo (ORCID: https://orcid.org/0000-0003-1761-6314)
- Shinji Sakamoto (ORCID: https://orcid.org/0000-0001-5498-551X)
- Izuru Nakamura (ORCID: https://orcid.org/0000-0002-3872-2434)
- Daisuke D. Ikeda
- Yoshitsugu Kojima (ORCID: https://orcid.org/0000-0002-0286-8765)
- N. Hashimoto (ORCID: https://orcid.org/0000-0003-4605-2378)
Institutions
- Otsuka (Japan) (JP)
- Okayama University (JP)
- Okayama University Hospital (JP)
- Okayama Psychiatric Medical Center (JP)
- Aichi Cancer Center (JP)
- Otsuka Pharmaceutical (Spain) (ES)
- Nagoya University (JP)
Publication Details
- Journal
- Addiction
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1111/add.70160
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kobayashi Foundation for Cancer Research
- Princess Takamatsu Cancer Research Fund