Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome
A Down syndrome-specific template was created. Longitudinal diffusion tensor imaging (DTI) and amyloid burden rates of change correlate. Longitudinal results show more significant regions than cross-sectional results. DTI and amyloid changes were found over two timepoints, 3.7 years apart on average. DTI and amyloid-PET offer greater sensitivity when tracking microstructural changes.
Authors
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Steven Kecskemeti (ORCID: https://orcid.org/0000-0003-3589-430X)
- Andrew K McVea (ORCID: https://orcid.org/0009-0008-4525-2793)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Andrew L. Alexander (ORCID: https://orcid.org/0000-0003-2695-768X)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- José Guerrero-González (ORCID: https://orcid.org/0000-0002-7405-7048)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Mark Mapstone
- Lisette LeMerise (ORCID: https://orcid.org/0009-0001-4443-0673)
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70572
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Institutes of Health