Impact of CYP2D6 genotype on fluoxetine exposure and treatment switch in adults and children/adolescents
The fluoxetine and norfluoxetine active moiety was unaffected by CYP2D6 genotype in adults and children/adolescents. Still, adult CYP2D6 PMs and UMs switched antidepressant treatment two to three times more often than NMs, indicating that relative levels of fluoxetine and norfluoxetine may affect treatment outcome rather than active moiety in relation to CYP2D6 phenotype.
Authors
- Pari Faraj
- Espen Molden (ORCID: https://orcid.org/0000-0001-6190-2751)
- Kristine Hole (ORCID: https://orcid.org/0000-0001-7300-5329)
- Karoline Linnea Nordby
Institutions
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- Diakonhjemmet Hospital (NO)
- Universidad Metropolitana (PR)
Publication Details
- Journal
- European Journal of Clinical Pharmacology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1007/s00228-025-03893-9
- Citations
- 2
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.11