Glucagon-like peptide-1 receptor agonists inhibit the progression of malignant pleural effusion in obese mice by regulating the metabolism of pleural effusion
The findings offer a deeper understanding of the metabolic characteristics of MPE in obese mice and clarify the metabolic mechanism underlying the inhibitory effect of GLP-1RA on MPE progression in this population. These insights may provide theoretical support for designing innovative approaches in the treatment of cancer patients with obesity or diabetes.
Authors
- Qingyu Chen (ORCID: https://orcid.org/0000-0002-6036-1516)
- Shu‐Feng Dong
- Rui-Qi Wei (ORCID: https://orcid.org/0000-0001-5780-5318)
- Feng‐Shuang Yi (ORCID: https://orcid.org/0000-0003-2822-5618)
- Mingming Shao (ORCID: https://orcid.org/0000-0002-4690-0245)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12967-025-06875-8
- Primary Topic
- Pleural and Pulmonary Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality