Comparative analysis of melatonin’s protective role against flattening filter and flattening filter-free X-ray induced nephropathy: focus on apoptosis and SIRT1 modulation
Melatonin has been proven to be an effective radioprotective agent against renal nephropathy and cellular apoptosis induced by FF and FFF beams. Additionally, pre-treatment with MEL has been shown to enhance SIRT1 expression, thereby protecting the kidneys from acute radiation damage, particularly from high-dose rate radiation.
Authors
- Tansel Sapmaz (ORCID: https://orcid.org/0000-0002-7820-5837)
- Sude Topkaraoğlu (ORCID: https://orcid.org/0000-0002-7680-7156)
- Kübra Şevgin (ORCID: https://orcid.org/0000-0001-8250-8227)
- Esra Erdem (ORCID: https://orcid.org/0000-0001-9031-9530)
- Serhat Aras (ORCID: https://orcid.org/0000-0002-4825-5921)
- Kübra Başol Baki (ORCID: https://orcid.org/0000-0002-3533-5260)
Institutions
- Bezmiâlem Vakıf Üniversitesi (TR)
- Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12882-025-04372-0
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91