Immune landscape in children with X-linked retinoschisis
Alterations were found in blood lymphocyte compositions of children with X-linked retinoschisis within both innate and adaptive immune axes. Some alterations including an elevation of CD4/CD8 ratio in X-linked retinoschisis mirror those previously found in adult patients with this disease. The fact that these abnormalities were present early in this disease indicates that retinoschisin-1 may play a role in regulating immunity in addition to retinal structure. The findings may have implications for future treatments such as ocular gene delivery.
Authors
- Sergei Syrbu (ORCID: https://orcid.org/0000-0003-4620-7923)
- Sarah A. Stanley (ORCID: https://orcid.org/0000-0002-4182-9048)
- Arlene V. Drack (ORCID: https://orcid.org/0000-0002-8195-8426)
- Ying Hsu (ORCID: https://orcid.org/0000-0002-0396-9680)
- Alina V. Dumitrescu (ORCID: https://orcid.org/0000-0002-7650-290X)
- Brianna Lobeck
- Christine A. Sinkey
- Giulia Del Valle
- Christopher R Fortenbach
Institutions
- University of Iowa (US)
- University of Washington (US)
- University of Iowa Hospitals and Clinics (US)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12865-025-00741-4
- Citations
- 1
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Research to Prevent Blindness
- Ögonfonden