CCT196969 inhibits TNBC by targeting the HDAC5/RXRA/ASNS axis to down-regulate asparagine synthesis
This study reveals a previously unrecognized anti-TNBC mechanism of CCT196969 through the HDAC5/RXRA/ASNS axis. This provides potential candidate targets for the treatment of TNBC and a theoretical basis for the clinical treatment of TNBC patients with CCT196969.
Authors
- Liyang Yin
- Yingying Shen (ORCID: https://orcid.org/0000-0003-2295-7316)
- Qi Wang (ORCID: https://orcid.org/0000-0001-7879-9973)
- Jun Li (ORCID: https://orcid.org/0000-0002-2121-3393)
- Qiong Yuan (ORCID: https://orcid.org/0009-0002-3868-0569)
- Shu Liu (ORCID: https://orcid.org/0009-0002-0353-6364)
- Xuyu Zu
Institutions
- University of South China (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s13046-025-03494-5
- Citations
- 1
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Health Commission of Hunan Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province