The Baeyer–Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols
The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer-Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we determine the relative migratory aptitude of cubyl groups in the Baeyer-Villiger oxidation and rationalize these experimental findings with computational studies.
Authors
- James A. Platts (ORCID: https://orcid.org/0000-0002-1008-6595)
- Jasmine Hind (ORCID: https://orcid.org/0009-0000-9553-4176)
- Matthew Tredwell (ORCID: https://orcid.org/0000-0002-4184-5611)
- Ian A. Fallis
Institutions
- University Hospital of Wales (GB)
- Centre de Recherche en Sciences et Technologies de l'Information et de la Communication (FR)
- Cardiff University (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c02760
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Engineering and Physical Sciences Research Council