Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2
Targeting the NOTCH1-KEAP1-NRF2 axis as a possible chronic hepatic injury therapy is supported by these findings, which identify NOTCH1-KEAP1 as an NRF2 suppressor that accelerates the progression of liver injury.
Authors
- Xiaojuan Yu (ORCID: https://orcid.org/0000-0001-9412-6170)
- Chunxiao Chang
- S. Qi (ORCID: https://orcid.org/0009-0005-9133-9222)
- Shengbin Shi
- Jun Xu (ORCID: https://orcid.org/0000-0003-3755-9660)
- Meng Wang (ORCID: https://orcid.org/0009-0003-3191-2272)
- Jia Li (ORCID: https://orcid.org/0000-0002-2652-0034)
Institutions
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1186/s13046-025-03488-3
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04