Chemical Composition, Antioxidant, and Anti-Alzheimer Potential of Acetone Extract of Tamarix Africana Seeds with Docking Approach: Cholinesterase Enzymes
Furthermore, these compounds may be pharmacologically useful. Molecular docking studies demon-strated that among the four tested plant-derived compounds, apigenin-7-O-glucoside, diosmin, neohesperidin, and rutin, apigenin-7-O-glucoside exhibited the highest binding affinity toward acetylcholinesterase (AChE), while diosmin showed the strongest interaction with butyrylcholinesterase (BChE). These findings underscore the therapeutic potential of selected plant bioactives as lead candidates in cholinesterase-targeted drug discovery. T. africana extract can be utilized as a possible source of substitute chemicals.
Authors
- Ouided Benslama (ORCID: https://orcid.org/0000-0002-7946-219X)
- Rabah Arhab
- Chawki Bensouıcı (ORCID: https://orcid.org/0000-0003-4612-4642)
- Rokayya Sami (ORCID: https://orcid.org/0000-0003-3162-9453)
- Abd El Hamid Khabtane
- Naseh A. Algehainy (ORCID: https://orcid.org/0000-0001-8557-0499)
- Esma Anissa Trad Khodja (ORCID: https://orcid.org/0000-0002-2504-3627)
- Mohamed Sabri Bensaad (ORCID: https://orcid.org/0000-0002-1171-2797)
- Nada Alqadri (ORCID: https://orcid.org/0000-0003-3607-2359)
- Roua S. Baty (ORCID: https://orcid.org/0000-0001-5324-0014)
- Zeyad M. Alharbi
- Ashwaq M. Al-Nazawi
- Mohammad Alanazi (ORCID: https://orcid.org/0000-0001-6766-3237)
- Abdulsalam Noorwali
Publication Details
- Journal
- Clinical Laboratory
- Published
- 2025-01-01
- DOI
- https://doi.org/10.7754/clin.lab.2025.250115
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00