Comparative evaluation of DNA and RNA probes for capture-based mitochondrial DNA next-generation sequencing
The systematic evaluation of DNA and RNA probes in capture-based mtDNA NGS provides valuable insights into their performance differences. These findings advocate for informed probe selection tailored to the specific experimental and clinical needs, ultimately advancing the field of mtDNA characterization and its applications in genomics and diagnostics.
Authors
- Wenjie Guo (ORCID: https://orcid.org/0000-0002-6484-4777)
- Shengjing Li
- Yang Liu
- Jinliang Xing (ORCID: https://orcid.org/0000-0001-8979-2056)
- Tianlei Sun
- Xu Guo (ORCID: https://orcid.org/0000-0003-4902-8859)
- Z Lei (ORCID: https://orcid.org/0009-0008-3692-5466)
- Kaixiang Zhou (ORCID: https://orcid.org/0009-0001-9612-3456)
- Jiamin Wang (ORCID: https://orcid.org/0009-0008-1697-4578)
Institutions
- Northwest University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12915-025-02365-x
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China