Histologic and immune characterization of cutaneous immune-related adverse events induced by immune checkpoint inhibitors
Compared with adjacent unaffected skin, CirAE lesions had significantly upregulated <i>THY1</i> (<i>CD90</i>) and increased M2 macrophages (adjusted p<0.05). Our findings suggest that CirAEs exhibit diverse histologic patterns that may mimic autoimmune skin diseases. The lack of distinct biomarker signatures may indicate complex and heterogeneous mechanisms underlying CirAEs; however, the upregulation of <i>THY1</i> and elevated numbers of M2 macrophages in CirAE lesions suggest <i>THY1</i> and M2 macrophages may be involved in the pathogenesis of these toxic effects. Further investigation to elucidate the molecular determinants of CirAEs and develop targeted therapeutic strategies is warranted.
Authors
- Aung Naing (ORCID: https://orcid.org/0000-0002-4803-8513)
- Nejla Ozirmak Lermi (ORCID: https://orcid.org/0000-0001-6820-1456)
- Dzifa Y. Duose (ORCID: https://orcid.org/0000-0002-6763-9736)
- Jonathan L. Curry (ORCID: https://orcid.org/0000-0003-0630-6222)
- Cara Haymaker (ORCID: https://orcid.org/0000-0002-1317-9287)
- Joud Hajjar (ORCID: https://orcid.org/0000-0003-4633-1043)
- Omar Pacha (ORCID: https://orcid.org/0000-0002-5230-0705)
- Anisha B. Patel (ORCID: https://orcid.org/0000-0002-5372-784X)
- Ken Chen (ORCID: https://orcid.org/0000-0001-5701-1438)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1136/jitc-2024-011401
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- University of Texas MD Anderson Cancer Center