Reduction of oxidative stress in total knee arthroplasty using tourniquet with a novel pharmaceutical combination
The attenuation of LOOH elevation, the faster PMN deactivation, the inhibition of ferritin release from the cells along with the improved clinical outcomes suggest that combined NAC and Deferiprone administration may reduce tourniquet-related oxidative stress and inflammation, enhancing early recovery in TKA patients.
Authors
- Electra Kalaitzopoulou (ORCID: https://orcid.org/0000-0002-7486-910X)
- Aristeidis Ntoukas (ORCID: https://orcid.org/0000-0003-1792-6208)
- John Lakoumentas (ORCID: https://orcid.org/0000-0003-0869-736X)
- Christos D. Georgiou (ORCID: https://orcid.org/0000-0001-9707-0109)
- Savvas Giakoumakis
- Irini Tatani (ORCID: https://orcid.org/0000-0001-5005-1007)
- Eleni Tsaliki (ORCID: https://orcid.org/0000-0001-9236-1628)
- Elias Panagiotopoulos (ORCID: https://orcid.org/0000-0002-1992-564X)
- Polyxeni Papadea (ORCID: https://orcid.org/0000-0002-5131-8196)
- Marianna Skipitari (ORCID: https://orcid.org/0000-0001-5077-1418)
- Athina Varemmenou (ORCID: https://orcid.org/0000-0002-6277-5894)
- Effimia Michail
Institutions
- University of Patras (GR)
- General University Hospital of Patras (GR)
Publication Details
- Journal
- SICOT-J
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1051/sicotj/2025042
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- European Commission
- State Scholarships Foundation
- Hellenic Foundation for Research and Innovation
- European Social Fund