α‐Synuclein Promotes the Expression and Release of Neurofilament Light Chain from Oligodendrocytes in a Murine Model: Implication for Multiple System Atrophy?
These findings suggest additional cellular roles for NfL in oligodendrocytes beyond its established function in neurons and have potential implications for the neurodegenerative pathophysiology of MSA. ANN NEUROL 2025;98:1364-1379.
Authors
- Bingxu Zhu
- Huihui Cai
- Tao Feng (ORCID: https://orcid.org/0000-0002-8530-4622)
- Wenyi Kou
- Yuanchu Zheng (ORCID: https://orcid.org/0000-0002-9080-6694)
- Zhenwei Yu (ORCID: https://orcid.org/0000-0001-9532-0100)
- Yang Chen (ORCID: https://orcid.org/0000-0003-3689-2680)
- Jiayi Wu (ORCID: https://orcid.org/0000-0001-9660-7066)
- Siming Li (ORCID: https://orcid.org/0000-0002-2879-2113)
- Yue Huang (ORCID: https://orcid.org/0000-0002-3913-9400)
- Guiwen Yang (ORCID: https://orcid.org/0000-0002-0957-6730)
Institutions
- The University of Sydney (AU)
- Capital Medical University (CN)
- UNSW Sydney (AU)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1002/ana.70029
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Beijing Postdoctoral Science Foundation
- Beijing Municipal Natural Science Foundation