Caloric Restriction Enhances the Efficacy of Antiandrogen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation
Fasting-induced caloric restriction reduces androgen receptor translation and enhances the activity of enzalutamide, suggesting that dietary intervention could be an effective strategy to enhance prostate cancer sensitivity to antiandrogen therapy. See related commentary by Anzules et al., p. 4045.
Authors
- David W. Goodrich (ORCID: https://orcid.org/0000-0002-1021-1827)
- Li Shen (ORCID: https://orcid.org/0000-0003-4182-6450)
- Luigi Fontana (ORCID: https://orcid.org/0000-0001-8500-5537)
- Roberto Pili (ORCID: https://orcid.org/0009-0004-9993-9911)
- Christopher Rupert (ORCID: https://orcid.org/0000-0003-4636-1189)
- Noah R. Sommers (ORCID: https://orcid.org/0000-0002-5510-4099)
- Angela J. Klunk (ORCID: https://orcid.org/0009-0008-2224-2699)
- Jagannath Misra (ORCID: https://orcid.org/0000-0001-9713-0298)
- Kirk A. Staschke (ORCID: https://orcid.org/0000-0001-8722-9585)
- Ricardo A. Cordova (ORCID: https://orcid.org/0000-0003-4959-309X)
- Sabrina Orsi (ORCID: https://orcid.org/0000-0001-6027-5258)
- May Elbanna (ORCID: https://orcid.org/0000-0002-9745-9066)
- Maria Tsompana (ORCID: https://orcid.org/0000-0001-7546-3198)
- Yanqing Wang (ORCID: https://orcid.org/0009-0006-7828-9977)
- Jocelyne N. Hanquier (ORCID: https://orcid.org/0000-0001-7195-482X)
- Ronald C. Wek
Institutions
- Indiana University Health (US)
- Roswell Park Comprehensive Cancer Center (US)
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- Indiana Cancer Consortium (US)
- Jacobs Institute (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1158/0008-5472.can-24-1986
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- U.S. Department of Defense
- Prostate Cancer Foundation
- Eli Lilly and Company
- Lilly Endowment
- Australian Youth and Health Foundation
- National Institutes of Health
- National Health and Medical Research Council