Topological and geometric signatures of brain network dynamics in Alzheimer's disease
Dynamic connectivity reveals sex-specific brain disruptions in Alzheimer's disease (AD). Peak-based analysis improves sensitivity over mean-based connectivity measures. Topological and geometric metrics capture distinct network disruptions by sex. Mild cognitive impairment shows less consistent connectivity changes due to diagnostic instability. Findings support dynamic magnetic resonance imaging (MRI) metrics as early AD biomarkers in future studies.
Authors
- Lynn Yi (ORCID: https://orcid.org/0000-0003-4575-0158)
- Yang Li (ORCID: https://orcid.org/0000-0002-9725-8774)
- Yutong Wu (ORCID: https://orcid.org/0000-0003-1215-8932)
- Tananun Songdechakraiwut
- Michael William Lutz (ORCID: https://orcid.org/0000-0001-8809-5574)
Institutions
- Social Science Research Council (US)
- Duke University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70545
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- National Institutes of Health
- Avid Radiopharmaceuticals