Targeting the <i>MCM10/p53/p21/CCND1</i> Axis in Colorectal Cancer: Evaluating the Therapeutic Potential of Ultrasound
These findings reveal that <i>MCM10</i> promotes CRC malignancy through inhibiting the tumor-suppressive <i>p53/p21/CCND1</i> pathway. Targeting this axis, particularly through ultrasound-enhanced delivery or sensitization strategies, holds promise as a novel therapeutic approach in CRC.
Authors
- Chiu-Ming Wen (ORCID: https://orcid.org/0000-0002-9756-6208)
- Hao Wu (ORCID: https://orcid.org/0000-0001-8951-3141)
- Zheng Jiang (ORCID: https://orcid.org/0009-0002-1216-2018)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Biotherapy and Radiopharmaceuticals
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1177/10849785251364091
- Citations
- 1
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67