Role of Gut‐Derived Endotoxins in Porto‐Sinusoidal Vascular Disorder: Comparison Between patients with and without portal hypertension
Even before the development of PH, patients with PSVD exhibit increased intestinal permeability and bacterial translocation, related platelet aggregation, and hypercoagulability, suggesting that endotoxemia may play a pivotal role in the pathogenesis of vascular alterations underlying PSVD. Moreover, this study indicates that PSVD without and with PH represent different stages of the same disease.
Authors
- Andrea Baiocchini (ORCID: https://orcid.org/0000-0002-8096-5675)
- Stefania Gioia (ORCID: https://orcid.org/0000-0002-3940-4390)
- Lorenzo Ridola (ORCID: https://orcid.org/0000-0002-8596-2609)
- Luca Di Tommaso (ORCID: https://orcid.org/0000-0002-9013-4728)
- Luigi Terracciano (ORCID: https://orcid.org/0000-0002-9393-9660)
- Guido Carpino (ORCID: https://orcid.org/0000-0001-8570-2519)
- Diletta Overi (ORCID: https://orcid.org/0000-0003-3561-8903)
- Maurizio Forte (ORCID: https://orcid.org/0000-0003-0739-0534)
- Giulia d’Amati (ORCID: https://orcid.org/0000-0002-6959-691X)
- Eugenio Gaudio (ORCID: https://orcid.org/0000-0001-6180-3091)
- Alessio Aghemo (ORCID: https://orcid.org/0000-0003-0941-3226)
- Roberto Carnevale (ORCID: https://orcid.org/0000-0002-6216-9595)
- Silvia Nardelli (ORCID: https://orcid.org/0000-0002-7038-9539)
- Oliviero Riggio (ORCID: https://orcid.org/0000-0003-0241-3223)
- Nicola Riccardo Pugliese (ORCID: https://orcid.org/0000-0001-6466-1412)
- Manuela Merli (ORCID: https://orcid.org/0000-0003-3173-9767)
- Antonio Marí (ORCID: https://orcid.org/0000-0002-0994-0715)
- Daniele Tavano
- Giacomo Frati (ORCID: https://orcid.org/0000-0001-5584-6060)
Institutions
- Humanitas University (IT)
- Istituto Neurologico Mediterraneo (IT)
- Carlo Forlanini Hospital (IT)
- IRCCS Humanitas Research Hospital (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Liver International
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1111/liv.70277
- Citations
- 4
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 5.29