The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach
These findings highlight childhood trauma as a primary driver of paranoia, with cannabis use amplifying its effects. While trauma had a strong direct impact, cannabis played a significant mediating role. Integrating standard THC units into psychiatric research and clinical assessments may enhance risk detection and refine intervention strategies, particularly for childhood trauma-exposed individuals.
Authors
- Isabelle Austin-Zimmerman (ORCID: https://orcid.org/0000-0002-3428-5070)
- H.‐E. Degen
- Luis Alameda (ORCID: https://orcid.org/0000-0002-8621-2885)
- Lucia Sideli
- Kim Wolff (ORCID: https://orcid.org/0000-0001-9080-4720)
- Robin M. Murray (ORCID: https://orcid.org/0000-0003-0829-0519)
- Tom P. Freeman (ORCID: https://orcid.org/0000-0002-5667-507X)
- Chloe C. Y. Wong (ORCID: https://orcid.org/0000-0003-4886-8506)
- Victoria Rodríguez (ORCID: https://orcid.org/0000-0003-0383-0846)
- Monica Aas (ORCID: https://orcid.org/0000-0002-2338-5826)
- Giulia Trotta (ORCID: https://orcid.org/0000-0003-2801-9718)
- Edoardo Spinazzola (ORCID: https://orcid.org/0000-0002-8070-0618)
- Brian Leung (ORCID: https://orcid.org/0000-0002-8323-9628)
- Zhikun Li (ORCID: https://orcid.org/0000-0002-1732-5931)
- Marta Di Forti (ORCID: https://orcid.org/0000-0002-3218-6925)
- Yifei Lang
Institutions
- Libera Università Maria SS. Assunta (IT)
- Chinese University of Hong Kong (HK)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- North East London NHS Foundation Trust (GB)
- Centre Hospitalier Universitaire Vaudois (CH)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Early Intervention Foundation (GB)
- Hospital Universitario Virgen del Rocío (ES)
- University of Bath (GB)
- Universidad de Sevilla (ES)
- University of Hong Kong (HK)
- University of Lausanne (CH)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725101190
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- South London and Maudsley NHS Foundation Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- King's College London
- Medical Research Council