Arterial stiffness moderates the link between NfL and cognition: The IGNITE study
ClinicalTrials.gov: NCT02875301 HIGHLIGHTS: Neurofilament light (NfL) and carotid-femoral pulse wave velocity (cfPWV) each correlate with poorer cognitive function in older adults. Higher cfPWV exacerbates the link between NfL and cognitive deficits. Arterial stiffness may worsen NfL-related cognitive decline. Findings reveal synergy between vascular and neurodegenerative aging markers. Examining NfL or cfPWV alone may miss their synergistic effects on cognition.
Authors
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- Alyssa B. Dufour (ORCID: https://orcid.org/0000-0001-8061-9599)
- George Grove (ORCID: https://orcid.org/0000-0002-5043-139X)
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Edward McAuley (ORCID: https://orcid.org/0000-0002-4574-3292)
- Audrey M. Collins
- Sandra A. Billinger (ORCID: https://orcid.org/0000-0002-1618-7207)
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Charles H Hillman
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Arthur F. Kramer (ORCID: https://orcid.org/0000-0001-5870-2724)
- Lewis Arnold Lipsitz (ORCID: https://orcid.org/0000-0003-2344-1274)
- John M. Jakicic (ORCID: https://orcid.org/0000-0001-6800-9368)
- Kelsey R. Sewell (ORCID: https://orcid.org/0000-0002-3859-5017)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Thomas G. Travison (ORCID: https://orcid.org/0000-0002-1030-7175)
- Amani M. Norling (ORCID: https://orcid.org/0000-0003-1638-5913)
- Shivangi Jain (ORCID: https://orcid.org/0000-0002-7585-3185)
- Haiqing Huang (ORCID: https://orcid.org/0000-0002-8932-7995)
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Lu Wan (ORCID: https://orcid.org/0000-0003-3151-1893)
- Anna L. Marsland
Institutions
- Northeastern University (US)
- Harvard University (US)
- University of Kansas (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Murdoch University (AU)
- Cornell University (US)
- Hebrew SeniorLife (US)
- University of Kansas Medical Center (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70554
- Citations
- 2
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- U.S. Department of Defense
- University of Kansas
- University of Pittsburgh
- National Institutes of Health
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke