Guided Discovery of Antidiabetic Sesquiterpenoids From <i>Lindera Aggregate</i> by Activity Labeled Molecular Networking
As results indicated, all the eight compounds showed significant antidiabetic effects, which were consistent with the obtained activity annotations by ALMN. The mechanism of the antidiabetic activity for 1-8 were further delved via Akt/GSK3β signal pathway, which can be observed as potential agents against the insulin resistance for the insulin resistance Type II diabetes.
Authors
- Lei Zhao (ORCID: https://orcid.org/0000-0003-0813-6140)
- Tao Yue
- G.A.S. Premakumara (ORCID: https://orcid.org/0000-0001-8761-6614)
- Jinqian Yu (ORCID: https://orcid.org/0000-0002-7709-4610)
- Xiao Dan Wang (ORCID: https://orcid.org/0000-0003-4236-2483)
- Yingjian Guo
- Sagdullaev Shamansur Shaksaidovich
Institutions
- Qingdao University of Science and Technology (CN)
- Qilu University of Technology (CN)
- Shandong Academy of Sciences (CN)
- Yunusov Institute of the Chemistry of Plant Substances (UZ)
- Shandong University of Science and Technology (CN)
- University of Colombo (LK)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1002/pca.70017
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Technology Research and Development Program of Shandong