Expansion of the antibacterial spectrum of symmetrical amino acid-paired antifungal peptides through structural optimization
Our findings demonstrated that T substitution and hydrophobic moment adjustment effectively enhanced antibacterial activity of the antifungal peptide P19, making peptide F4 a strong candidate for both fungal and bacterial infections.
Authors
- Liang Luo (ORCID: https://orcid.org/0000-0002-8848-5510)
- Ziyi Sun
- Jiawen Luo (ORCID: https://orcid.org/0000-0003-4736-1404)
- Tiexiang Zhan
- Shuhe Li
- Derong Gao (ORCID: https://orcid.org/0009-0006-9068-3870)
- Shuli Chou (ORCID: https://orcid.org/0000-0001-8708-8241)
- Zheng Xu (ORCID: https://orcid.org/0000-0003-2837-8067)
- Xueqin Gao (ORCID: https://orcid.org/0000-0001-5833-1548)
- Qinghua Jiang (ORCID: https://orcid.org/0000-0001-9461-1563)
- Xiaodie Zeng (ORCID: https://orcid.org/0009-0000-8350-6303)
- Jiahao Hu
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- University of Exeter (GB)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1186/s12866-025-04160-8
- Citations
- 1
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.18