SETD2 drives METTL14-mediated m6A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension
This study identifies a novel SETD2/H3K36me3/METTL14/m<sup>6</sup>A axis that stabilizes Piezo1 mRNA, promoting Ca²⁺-dependent TGM2 activation and PASMC proliferation in PAH. Targeting this pathway-via SETD2, METTL14, or Piezo1 inhibition-may offer therapeutic potential to ameliorate vascular remodeling in PAH.
Authors
- Qicai Wu (ORCID: https://orcid.org/0000-0002-8830-3107)
- Xueliang Zhou
- Shuaishuai Zhao (ORCID: https://orcid.org/0009-0006-0996-9223)
- Jinlong Liu (ORCID: https://orcid.org/0000-0002-3585-3447)
- Chuan Yuan
Institutions
- Shanghai University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1007/s00018-025-05809-3
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province