Medium‐Chain Fatty Acids Ameliorate Liver Fibrosis by Phosphorylating Hepatic Stellate Cell Forkhead Box Protein <scp>O1</scp>
MCFAs, particularly C10, may modulate hHSC transcriptional inactivation through phosphorylation of the Akt-FOXO1 pathway. This mechanism of regulating the hHSC function via C10 might represent a novel therapeutic approach for liver fibrosis.
Authors
- Masahito Noguchi (ORCID: https://orcid.org/0000-0003-4129-3279)
- Mayumi Homma
- Aya Miyauchi
- Masashi Sakaki (ORCID: https://orcid.org/0000-0002-4431-3493)
- Momoko Kobayashi
- Toshiko Yamochi
- Joo‐ri Kim‐Kaneyama (ORCID: https://orcid.org/0000-0003-3141-8306)
- Akira Miyazaki (ORCID: https://orcid.org/0000-0002-7232-128X)
- Hitoshi Yoshida
- Xiao‐Feng Lei (ORCID: https://orcid.org/0000-0001-7568-0336)
Institutions
- SHOWA Medical University (JP)
- SHOWA Medical University Hospital (JP)
Publication Details
- Journal
- Liver International
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1111/liv.70270
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science