Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis
This study demonstrates that diazepam can partially restore hippocampal CA1 dysconnectivity in CHR-P individuals, suggesting that modulation of GABAergic function might be useful in the treatment of this clinical group.
Authors
- Maria Antonietta Nettis (ORCID: https://orcid.org/0000-0002-5401-8391)
- Gemma Modinos (ORCID: https://orcid.org/0000-0002-7870-066X)
- Nicholas R Livingston (ORCID: https://orcid.org/0000-0002-6582-2545)
- Anthony A. Grace (ORCID: https://orcid.org/0000-0003-1864-5504)
- Luke A. Jelen (ORCID: https://orcid.org/0000-0001-6398-5239)
- Thomas J. Reilly (ORCID: https://orcid.org/0000-0001-6890-918X)
- Gabriel A. Devenyi (ORCID: https://orcid.org/0000-0002-7766-1187)
- Cecilia Casetta (ORCID: https://orcid.org/0000-0002-1980-3415)
- Owen O’Daly (ORCID: https://orcid.org/0000-0001-5690-1252)
- Steven Williams (ORCID: https://orcid.org/0000-0003-4299-1941)
- Amanda Kiemes (ORCID: https://orcid.org/0000-0001-6819-8090)
- Samuel Knight (ORCID: https://orcid.org/0000-0003-3420-3722)
- Paolo Fusar‐Poli (ORCID: https://orcid.org/0000-0003-3582-6788)
- Alice Egerton (ORCID: https://orcid.org/0000-0003-2939-064X)
- Paulina B. Lukow (ORCID: https://orcid.org/0000-0002-6796-9102)
- Thomas Spencer (ORCID: https://orcid.org/0000-0001-5661-3293)
- Andrea De Micheli (ORCID: https://orcid.org/0000-0002-8358-5715)
- Philip K. McGuire (ORCID: https://orcid.org/0000-0003-4381-0532)
- Aikaterini Dima (ORCID: https://orcid.org/0000-0002-6371-775X)
- M. Mallar Chakravarty
Institutions
- National Health Service (GB)
- University of Pittsburgh (US)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- University of Pavia (IT)
- Douglas Mental Health University Institute (CA)
- University of Oxford (GB)
- University College London (GB)
- McGill University (CA)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725101268
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- McGill University
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Royal Society
- European Commission
- U.S. Public Health Service
- NIHR Maudsley Biomedical Research Centre
- Canadian Institutes of Health Research
- Medical Research Council
- National Institute of Mental Health