<scp>CXCL16</scp> Producing Tumor Clones Are Shaping Immunosuppressive Microenvironment in Squamous Cell Carcinoma via <scp>CXCR6</scp> Regulatory T Cell
We suggest COL6A1 and ITGA5 promote the invasive and metastatic property of SCC. We also uncovered how SCC recruits Tregs via the CXCL16/CXCR6 axis to create a TME favorable for its survival. These molecules can be used as potential therapeutic targets for treatment of SCC.
Authors
- Hyun Seung Choi (ORCID: https://orcid.org/0000-0002-6217-4714)
- Ji‐Ung Park (ORCID: https://orcid.org/0000-0002-6403-4918)
- Chung‐Gyu Park (ORCID: https://orcid.org/0000-0003-4083-8791)
- Hyunsung Nam (ORCID: https://orcid.org/0000-0003-0179-6971)
- Ki‐Myo Kim
- Mi Hyun Lee (ORCID: https://orcid.org/0000-0001-9747-2888)
- Jade N. Young (ORCID: https://orcid.org/0000-0002-8595-6196)
- Seung Ki Min (ORCID: https://orcid.org/0000-0002-9638-9668)
- Nicholas Gulati (ORCID: https://orcid.org/0000-0002-4347-0710)
- Dina Poplausky (ORCID: https://orcid.org/0000-0002-5037-1630)
- Su Hwan Hwang
- Sun-Young Jung
- Jun Ho Park (ORCID: https://orcid.org/0000-0003-0235-1261)
- Hyun Je Kim (ORCID: https://orcid.org/0000-0002-4184-6702)
Institutions
- Seoul National University (KR)
- Cancer Research Institute (US)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71060
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80